The difficult balance between thrombosis and bleeding after transcatheter aortic valve replacement: A translational review

The difficult balance between thrombosis and bleeding after transcatheter aortic valve replacement. TAVR: transcatheter aortic valve replacement.

     

Use of proton pump inhibitors and risk of rosacea: A nationwide population-based study

Proton pump inhibitors (PPI) are commonly used drugs. However, little is known about the association between PPI use and rosacea. This study aimed to investigate the association between PPI use and rosacea risk. Patients with prior PPI therapy, including 1067 rosacea cases and 4268 matched controls, were identified from the National Health Insurance Research Database in Taiwan. The cumulative defined daily dose (cDDD) was used to quantify the PPI use. Logistic regression was used for the analyses. After adjustment for potential confounders, PPI use with cDDD of more than 365 was significantly associated with an increased risk of rosacea (odds ratio [OR], 1.54; 95% confidence interval [CI], 1.10–2.15). Rosacea risk was significantly associated with PPI use of cDDD of more than 365 in women (OR, 1.62; 95% CI, 1.08–2.46) but not in men. Stratified by PPI indications, risk of rosacea was significantly associated with PPI use of cDDD of more than 365 for peptic ulcer (OR, 1.58; 95% CI, 1.12–2.21). In conclusion, prolonged PPI use was associated with an increased risk of rosacea, particularly in women and patients with peptic ulcers.     

血液净化中心设备管理研究进展

血液净化中心是医院血液透析患者开展血液净化治疗的主要场所。在血液净化中心开展血液净化治疗的患者通常来说免疫功能低下,容易发生感染,并且对设备具有较强的依赖性。因此血液净化中心设备管理质量直接影响着血液透析中心的血液净化治疗效果。这便要求血液净化中心应该不断加强设备管理,提高设备管理质量,为患者的治疗提供更好的服务。因此近些年人们对于血液净化中心设备管理的重视程度不断提高,很多专家关于血液净化中心的设备管理开展了很多研究工作,本文将近些年的研究进展进行综述,以期为血液净化中心的设备管理提供借鉴。     

Alcohol,tobacco and coffee consumption and liver disease severity among individuals with Chronic Hepatitis B infection in North America

Introduction and objectivesThe prevalence of alcohol, tobacco, and coffee use and association with liver health among North Americans with Chronic Hepatitis B (CHB) infection has not been well described.Materials and methodsThe Hepatitis B Research Network includes an observational study of untreated CHB adults enrolled at 21 sites in the United States and Canada. Alcohol use was categorized as none, moderate, and at-risk based on the definition from the National Institute on Alcohol Abuse and Alcoholism; tobacco use as never, current and former; coffee use as none, 1–2 cups/day, and ≥3 cups/day. Linear regression and linear mixed models were used to associate lifestyle behaviors with ALT and FIB-4 values.Results1330 participants met eligibility: 53% males, 71% Asian and the median age was 42 years (IQR: 34–52). Median ALT was 33 U/L (IQR: 22–50), 37% had HBV DNA <10³ IU/mL, 71% were HBeAg negative, and 65% had a FIB-4 <1.45. At baseline, 8% of participants were at-risk alcohol drinkers, 11% were current smokers and 92% drank <3 cups of coffee/day. Current tobacco and ‘at-risk’ alcohol use, were significantly associated with elevated ALT levels in univariable analyses, however, these associations were not statistically significant when controlling for sociodemographic and HBV characteristics.ConclusionsIn this large diverse cohort of untreated CHB participants, at-risk alcohol use, current tobacco use and limited coffee consumption did not have an association with high ALT and FIB-4 values. In contrast, significant associations were found between the frequency of these lifestyle behaviors and sociodemographic factors.     

新型冠状病毒肺炎药物治疗研究进展

目前，尚未有确认对新型冠状病毒肺炎有效的抗病毒治疗与疫苗预防手段。结合以往冠状病毒治疗的循证证据及临床一线治疗经验制定治疗方案，现就新型冠状病毒肺炎药物治疗研究进展进行综述，具体从核苷逆转录酶抑制剂、核苷类似物等抗病毒药物，以及恢复期血浆治疗等方面进行介绍。     

静脉血栓栓塞症风险评估模型研究进展与启示

通过文献研究，总结国内外静脉血栓栓塞症各类评估工具的优缺点及适用范围。指出我国与欧美国家人群存在种族、疾病谱和遗传因素等方面的差异，国外量表所纳入的危险因素并不一定能准确、完整地反映我国患者的风险状况。应借鉴国外评估工具的构建方法，基于我国VTE患者数据进行多中心、大样本的回顾性研究，从而构建更适合我国人群的、更准确的VTE风险评估模型。     

功能失调性子宫出血的发病机制及治疗进展

功能失调性子宫出血(功血)是一种常见的妇科内分泌疾病,近年来其发病率逐年上升。其发病机制不明,可能包括神经内分泌功能失调和子宫内膜局部微环境异常两个方面。功血的治疗主要分为药物治疗及非药物治疗,后者包括左炔诺孕酮宫内释放系统、诊断性刮宫术、子宫内膜去除术、介入治疗及子宫切除术。其中高强度聚焦超声子宫内膜去除术是一种新兴技术,可在临床中进一步推广应用。